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14390 Mayo Boulevard  Jacksonville  Florida  32224  USA 

Our best rate. Guaranteed.


To make reservations by phone, call 1-800-321-2211 in the USA and Canada (or any of our worldwide reservation telephone numbers).

Step up your stay at our hotel near Mayo Clinic Jacksonville

  • Stay in one of our 134 well-appointed rooms or 12 suites at our Mayo Clinic Jacksonville, FL hotel.
  • Enjoy our Mayo Clinic accommodations, featuring signature Marriott bedding with cotton-rich linens.
  • Take advantage of in-room amenities, including coffee/tea maker, hair dryer, and iron/ironing board.
  • Work and relax in thoughtfully-designed guest rooms, ideal for business and leisure travelers.
  • Watch your favorite show or movies on in-room flat-screen TVs with premium movie channels.
  • Stay productive with large work desks, 2-line phones with voicemail, and free high-speed Internet.
  • This hotel has a smoke-free policy
  • Book 10 or more rooms at this hotel

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Get 25% off if you find a better deal anywhere else on Marriott rooms. We'll match it + and save you even more. View Brand Exclusions & Terms.