Discover a premier hotel in downtown St. Louis, situated in the heart of the city center amongst upscale Washington Avenue restaurants, nightlife, and attractions including the Gateway Arch. The Renaissance St. Louis Grand, a classic luxury Union Station hotel in St. Louis, blends unique amenities with classic style, from the opulent lobby to the tastefully decorated accommodations. Unwind in stylish St. Louis, MO hotel rooms or suites, featuring Aveda bath products and plush bedding for an invigorating night of rest and relaxation. Discover one of the premier St. Louis downtown hotels where guests can rejuvenate in the indoor pool or entice the palate at our fine downtown restaurant. Boasting over 50,500 square feet of innovative meeting space, the Renaissance features the Majestic Ballroom, accommodating up to 2,500 guests, and the Crystal Ballroom, with its stunning city views. For a historic hotel experience in downtown St. Louis, MO, the Renaissance St. Louis Grand is the ultimate destination.