441 West Center Street, Rochester, Minnesota 55902 USA
+1 507-292-1400

Thrive on long-stays

Marriott Rewards Category 5 · Points needed per night

Discover the newly renovated Residence Inn Rochester Mayo Clinic Area, the ideal choice for downtown Rochester, MN hotels. It combines the familiar comforts of home with passionate guest service whether your stay is for one night or thirty. Relax in your choice of 89 spacious with studio, one, and two-bedroom options. Only 9 miles from the Rochester International Airport (RST) and providing direct access to the world-famous Mayo Clinic via the climate-controlled pedestrian walkways and skyway, the Residence Inn Rochester Mayo Clinic Area is in a perfect downtown location. In addition, our hotel in downtown Rochester, MN is also centrally located to St. Mary’s Hospital and Rochester Methodist Hospital and is designed as an extended stay hotel. Nearby attractions include Mayowood Mansion, Assisi Heights, and Silver Lake Park. For nearby shopping visit The Grand Shops or Apache Mall. Graham Arena & the Olmsted County Fairgrounds are 2 miles away. We look forward to your stay at our Residence Inn.

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Guest Reviews

Confirmed Guest Reviews
4.5 out of 5.0
94% of guests recommend this hotel

Hear from our guests about their stay from 218 confirmed guest reviews

Key Amenities

  • Free high-speed internet
  • Free breakfast
  • Pet friendly
  • Kitchen/kitchenette


  • Take advantage of free Internet, grocery service and our downtown Rochester, MN location.

  • Our hotel near Mayo Clinic is connected to the world-famous medical facility via walkway.

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  • Newly renovated rooms and lobby at our hotel in downtown Rochester, MN.

Guest Rooms

  • Residence Inn Bedroom


    1 Queen, Sofa bed, City view
  • Residence Inn Bedroom

    1 Bedroom Suite

    1 Queen, Sofa bed, City view
  • Residence Inn Bedroom

    2 Bedroom Suite

    Bedroom 1: 1 Queen, Bedroom 2: 1 Queen, Sofa bed, Bathrooms: 2, City view

Check Room Rates & Availability

Residence Inn® by Marriott® Rochester Mayo Clinic Area