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Welcome to Mystique, a Luxury Collection Hotel, Santorini

Shaped by nature, enhanced by style

Carved into the rugged Caldera cliffs, Mystique, a Luxury Collection Hotel, overlooks the turquoise expanse of the Aegean Sea that encircles the island of Santorini. Designed using Cycladic architecture, where gentle curves and sculpted arches blend with a muted colour palette and light enhancing spaces, the hotel is a favoured destination for honeymoons and romantic escapes, emanating a carefree spirit and exclusive feel, while offering gloriously open horizons. Linked by a network of cobbled pathways, Mystique’s 41 suites and villas, the two swimming pools, the rejuvenating Elios Spa, the state-of-the-art gym, all boast panoramic sea views across to the active volcano that has shaped this exceptional island. The inspired dining options include Charisma for the freshest Greek-inspired cuisine, Lure by Olivier Campanha, a high-end gastronomical experience highlighting the region’s rich epicurean heritage, while Captain’s Lounge, occupying the site of a century-old mansion, caters for casual dining.

Rooms & Suites

Uncommon Accommodations

A favored destination for honeymoons and romantic escapes, Mystique emanates a carefree spirit, imparting an understated, exclusive feel, so reminiscent of the spectacular location.

Suites & Villas with Natural, Bespoke Design

An exclusive hideaway in the natural world, Mystique perfectly lends itself to wider exploration, offering a tantalizing insight into the captivating island of Santorini and its unique traditions, romance and wild beauty. The design follows the emblematic Cycladic architecture, where gentle curves and sculpted arches blend with a muted color palette and light enhancing spaces.

Secrecy Villa

Natural Materials and Contemporary Twist

Generating space and light into each guest room, the interiors are a combination of traditional regional charm and natural untamed materials with a contemporary twist and up-to-the-minute technology. Mystique's furniture are created by Frank Lefebvre, who is a nature-inspired designer. Each item showcases Lefebvre’s unique passion to breathe new life into natural materials, such as driftwood, and combine it with pebbles and lacquered wood to bring nature to the hotel’s interiors.

Mystery Villa Bedroom

Breathtaking Location, Awe-Inspiring Views

Overlooking the Sea

Carved into the rugged Caldera cliffs of Oia in Santorini, Mystique overlooks the turquoise expanse of the Aegean Sea that encircles the island of Santorini. Mystique's iconic location on the lower side of the Caldera offers unobstructed, infinity views to the Aegean Sea and the volcano, that are enjoyed from every spot of the hotel, including all restaurants and bars, the spa and fitness center among others.

Hotel View

Captivating Romance

The unique Oia scenery imparts a tranquil and discreet quality to Mystique that overlooks the breathtaking Santorini panorama, making it an ideal setting for intimate, romantic escapes.

Main Infinity Pool

Mediterranean Dining

Inspired dining options exalted by authentic, Greek-influenced cuisine are available whether guests choose to eat in the privacy of their own terrace or at one of Mystique’s restaurants. Most of the vegetables and herbs used to prepare the refined dishes at Mystique’s restaurants, are cultivated in the hotel’s organic farm in the village of Megalohori. Santorini’s rich volcanic soil combined with the Mediterranean climate of the region, have proved nourishing sources for produce of unique and distinctive tastes and aromas.

Pools Hanging From the Cliff

Main Infinity Pool

Infinity-Edge Pool

Santorini’s alluring beauty is highlighted at the hotel's two pools, one of which is infinity-edge.

Holistic Villa

Captivating Views

Perched on the volcanic cliff above the Azul blue Aegean Sea, Mystique’s pools offer captivating views to the Caldera and the volcano.

Infinity pool

Ideal Sightseeing

With sun-beds and Aura Bar by the one pool and Captain's Lounge by the other one, they constitute the ideal spots for Santorini to show its magic.

A Unique Spa Experience

Relax and Unwind

Organic and regionally derived, the therapeutic ingredients used in the hotel’s Elios Spa provide signature treatments for whole body relaxation rituals.

Elios Spa

Rich History

An immense volcanic eruption over three and a half thousand years ago, around 1645 BC, formed what are now Santorini’s beautiful trademarks: striking cliffs and dramatic coasts. Some say that this was the eruption that led to the demise of the lost city of Atlantis. True or not, Santorini is bathed in history, and Mystique has the distinct advantage of being right in the middle of it all.

Local Area

Exhilarating Functions

Plan the event of a lifetime at our breathtaking Santorini Island Hotel.



Mystique, a Luxury Collection Hotel, Santorini

Oia, Santorini Island, Santorini, Greece, 84702

Tel: +30 228-6071114
Distance from Property: 16 KM
Visit Website
Airport Shuttle: €100
Alternate Airport Transportation

Private Car Service (3 pax - 100 / € 4-6 pax - 150 €)


Private Car Service
Limousine/Van Service


Bus Station

Oia Bus Station


Plan and Prepare for your Stay

About Ownership

A series of serendipitous events led Kalia and Antonis Eliopoulos to hospitality, armed with a natural talent for piecing together a compelling narrative. It was the pull of Santorini, a mesmerizing island Antonis Eliopoulos had been visiting since childhood, that changed their destiny. On one of his countless trips here, he decided to buy a rustic vineyard, which turned into their first hotel in 1993 – Vedema, a Luxury Collection Resort, a unique village-like setting loved by locals and guests alike. Their passion for hospitality motivated them to take on the iconic Oía village, where they introduced in 2007 Mystique, a Luxury Collection Hotel, a secluded hideaway carved into the rugged caldera cliffs and boasting glorious views to the infinite blue of the Aegean archipelago.


Additional Properties

The duo knew that their third hotel on the volcanic island, Istoria, a Member of Design Hotels, had to be on the magical black sand beach of Perivolos, where they transformed a former palazzo of a legendary socialite to a serene retreat for sophisticated travelers. Wishing to expand their horizons, in 2018 they journeyed to the nearby island of Paros, for their fourth property, Parīlio, a Member of Design Hotels, opened in July 2019, where they crafted an artful statement amid a world of pine-fringed coves and white-washed historical villages.

Hotel Overview

Property Details



Fitness Center

Outdoor Pool

Daily Housekeeping

Turndown Service


Gift Shop

Dry Cleaning Service


Room Service

Wake up Calls

Service Request

Check-in: 3:00 pm

Check-out: 11:00 am

Smoke Free Property

Pet Policy

Pets Not Allowed

Pets are not allowed.

Parking Valet

Daily: €15

Policies and Payments

Accepts: Credit Cards

Contactless mobile payments


Concierge desk service

Currency Exchange

Languages spoken by staff:
English, Greek, French, Spanish, Turkish

For more information about the physical features of our accessible rooms, common areas or special services relating to a specific disability please call +30 228-6071114

Accessible Areas with Accessible Routes from Public Entrance

Main Entrance is Accessible

Guest Room Accessibility

Alarm Clock Telephone Ringers

Bathtub Grab Rails

Deadbolts on Guest Room and Suites Doors

Lowered Electrical Outlets

Non-slip Grab Rails in the Bathroom

Room Windows Open

Safety Chains and/or Latches on Guest Doors

Viewports in Guest Room and Suites Doors


Carbon Footprint: 21.34 kg per room night

Water Footprint: 1500.8 liters per room night

Mystique, a Luxury Collection Hotel, Santorini