Mystique, a Luxury Collection Hotel, Santorini

Shaped by nature, enhanced by style

Carved into the rugged Caldera cliffs, Mystique, a Luxury Collection Hotel, overlooks the turquoise expanse of the Aegean Sea that encircles the island of Santorini. Designed using Cycladic architecture, where gentle curves and sculpted arches blend with a muted colour palette and light enhancing spaces, the hotel is a favoured destination for honeymoons and romantic escapes, emanating a carefree spirit and exclusive feel, while offering gloriously open horizons. Linked by a network of cobbled pathways, Mystique’s 41 suites and villas, the two swimming pools, the rejuvenating Elios Spa, the state-of-the-art gym, all boast panoramic sea views across to the active volcano that has shaped this exceptional island. The inspired dining options include Charisma for the freshest Greek-inspired cuisine, Lure by Olivier Campanha, a high-end gastronomical experience highlighting the region’s rich epicurean heritage, while Captain’s Lounge, occupying the site of a century-old mansion, caters for casual dining.

Rooms and Suites

Uncommon Accommodations

A favored destination for honeymoons and romantic escapes, Mystique emanates a carefree spirit, imparting an understated, exclusive feel, so reminiscent of the spectacular location.

Suites & Villas with Natural, Bespoke Design

An exclusive hideaway in the natural world, Mystique perfectly lends itself to wider exploration, offering a tantalizing insight into the captivating island of Santorini and its unique traditions, romance and wild beauty. The design follows the emblematic Cycladic architecture, where gentle curves and sculpted arches blend with a muted color palette and light enhancing spaces.

Secrecy Villa siting area and dining table.

Natural Materials and Contemporary Twist

Generating space and light into each guest room, the interiors are a combination of traditional regional charm and natural untamed materials with a contemporary twist and up-to-the-minute technology. Mystique's furniture are created by Frank Lefebvre, who is a nature-inspired designer. Each item showcases Lefebvre’s unique passion to breathe new life into natural materials, such as driftwood, and combine it with pebbles and lacquered wood to bring nature to the hotel’s interiors.

Mystery Villa Bedroom with a king bed, rustic décor, and a view of the water.

Breathtaking Location, Awe-Inspiring Views

Overlooking the Sea

Carved into the rugged Caldera cliffs of Oia in Santorini, Mystique overlooks the turquoise expanse of the Aegean Sea that encircles the island of Santorini. Mystique's iconic location on the lower side of the Caldera offers unobstructed, infinity views to the Aegean Sea and the volcano, that are enjoyed from every spot of the hotel, including all restaurants and bars, the spa and fitness center among others.

Hotel sign beside a view of the water and outdoor seating.

Captivating Romance

The unique Oia scenery imparts a tranquil and discreet quality to Mystique that overlooks the breathtaking Santorini panorama, making it an ideal setting for intimate, romantic escapes.

Main Infinity Pool from above.

Mediterranean Dining

Inspired dining options exalted by authentic, Greek-influenced cuisine are available whether guests choose to eat in the privacy of their own terrace or at one of Mystique’s restaurants. Most of the vegetables and herbs used to prepare the refined dishes at Mystique’s restaurants, are cultivated in the hotel’s organic farm in the village of Megalohori. Santorini’s rich volcanic soil combined with the Mediterranean climate of the region, have proved nourishing sources for produce of unique and distinctive tastes and aromas.

soap bottle icon

Commitment to Clean

As we welcome you back to our hotels around the world, we are committed to providing you with a safe environment that aligns with expert protocols for working to defeat COVID-19. Click to see updates and learn more about what to expect at our hotel.

Pools Hanging From the Cliff

Main Infinity Pool at sunset.

Infinity-Edge Pool

Santorini’s alluring beauty is highlighted at the hotel's two pools, one of which is infinity-edge.

Infinity pool looking over the water and mountains.

Captivating Views

Perched on the volcanic cliff above the Azul blue Aegean Sea, Mystique’s pools offer captivating views to the Caldera and the volcano.

Infinity pool edge looking over the water.

Ideal Sightseeing

With sun-beds and Aura Bar by the one pool and Captain's Lounge by the other one, they constitute the ideal spots for Santorini to show its magic.

A Unique Spa Experience

Relax and Unwind

Organic and regionally derived, the therapeutic ingredients used in the hotel’s Elios Spa provide signature treatments for whole body relaxation rituals.

Elios Spa treatment room with a massage table.

Rich History

An immense volcanic eruption over three and a half thousand years ago, around 1645 BC, formed what are now Santorini’s beautiful trademarks: striking cliffs and dramatic coasts. Some say that this was the eruption that led to the demise of the lost city of Atlantis. True or not, Santorini is bathed in history, and Mystique has the distinct advantage of being right in the middle of it all.

Local Area mountainside cityscape.

Exhilarating Functions

Plan the event of a lifetime at our breathtaking Santorini Island Hotel.

Outdoor seating.
Offers and Packages

Luxury Holidays

Available: April 8, 2022November 8, 2022

Pamper yourself in an extended luxury getaway in the exclusive Mystique located on a legendary setting on the Caldera cliffs of Oia while we offer you the 7th night for free!

Come Explore Our Villas

Available: January 7, 2022November 12, 2022

Explore our signature pool villas and enjoy the most sensorial experience of Santorini on this exclusive hideaway on the rugged caldera cliffs of Oia!

Honeymoon Package

Available: January 7, 2022November 12, 2022

Indulge in an extraordinary honeymoon and let us pamper you with all the attention and comfort you deserve, while enjoying the privacy of this secluded haven!

Our Location

Getting Here

Mystique, a Luxury Collection Hotel, Santorini

Oia, Santorini Island,Santorini Greece 84702

Tel: +30 228-6071114
Distance from Property: 16 Miles
Alternate Airport Transportation

Private Car Service (per way for up to 3 people)


Private Car Service
Limousine/Van Service


Bus Station

Oia Bus Station

About Ownership

A series of serendipitous events led Kalia and Antonis Eliopoulos to hospitality, armed with a natural talent for piecing together a compelling narrative. It was the pull of Santorini, a mesmerizing island Antonis Eliopoulos had been visiting since childhood, that changed their destiny. On one of his countless trips here, he decided to buy a rustic vineyard, which turned into their first hotel in 1993 – Vedema, a Luxury Collection Resort, a unique village-like setting loved by locals and guests alike. Their passion for hospitality motivated them to take on the iconic Oía village, where they introduced in 2007 Mystique, a Luxury Collection Hotel, a secluded hideaway carved into the rugged caldera cliffs and boasting glorious views to the infinite blue of the Aegean archipelago.

Hotel aerial view.

Additional Properties

The duo knew that their third hotel on the volcanic island, Istoria, a Member of Design Hotels, had to be on the magical black sand beach of Perivolos, where they transformed a former palazzo of a legendary socialite to a serene retreat for sophisticated travelers. Wishing to expand their horizons, in 2018 they journeyed to the nearby island of Paros, for their fourth property, Parīlio, a Member of Design Hotels, opened in July 2019, where they crafted an artful statement amid a world of pine-fringed coves and white-washed historical villages.

Hotel aerial view after dark.

Property Details



Private Spaces Designated in Spa and Wellness Areas

Fitness Center

Outdoor Pool

24 Hour Room Service

Daily Housekeeping

Turndown Service


Business Center

Gift Shop

Dry Cleaning Service


Room Service

Wake up Calls

Service Request

Check-in: 3:00 pm

Check-out: 11:00 am

Smoke Free Property

Pet Policy

Pets Not Allowed

Parking Valet

Daily: €15

Policies and Payments

Accepts: Credit Cards

Contactless mobile payments


Concierge desk service

Currency Exchange

Languages spoken by staff:
English, Greek, French, Spanish, Turkish

For more information about the physical features of our accessible rooms,common areas,or special services relating to a specific disability,please call +30 228-6071114

Accessible Hotel Features

Accessible on-site parking

Property has elevators

Self Operating lift or a sloped entry in hotel swimming pools

Service Animals are Welcome

Valet parking for vehicles outfitted for drivers in wheelchairs

Van Accessible on-site parking

Accessible Areas with Accessible Routes from Public Entrance

Accessible Entrance to On-Site Pool

Entrance to On-Site Business Center is Accessible

Entrance to On-Site Fitness Center is Accessible

Entrance to On-Site Spa is Accessible

Main Entrance is Accessible

Meeting Spaces are Accessible

On-Site Restaurants are Accessible

Room and Suites Access through the Interior Corridor

Guest Room Accessibility

Accessible Vanities

Adjustable HIght Hand-Held Shower Wand

Alarm Clock Telephone Ringers

Bathtub Grab Rails

Bathtub Seat

Close Caption TV

Deadbolts on Guest Room and Suites Doors

Electronic Room Key

Flashing Door Knockers

Guest Room and Suites Doors Self-Closing

Hearing Accessible Rooms and/or Kits

Lever Handles on Guest Room Doors

Lowered Deadbolts on Guest Room Doors

Lowered Electricat Outlets

Lowered Night Guards on Guest Room Doors

Lowered Viewports in Guest Room Doors

Mobility accessible rooms

Non-slip Grab Rails in the Bathroom

Roll-in Shower

Room Windows Open

Safety Chains and/or Latches on Guest Doors

Secondary Locks on Room Windows

TTY/TTD Compatible

Toilet Seat at Wheelchair Height - Toilet for Disabled

Transfer Showers in Guest Rooms

Viewports in Guest Room and Suites Doors